The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season. The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. Can Houston maintain its undefeated against the spread record and which other Week 4 NFL spreads should you keep a close eye on? All of the Week 4 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 4 NFL picks now. The Chargers are as beat up as any team in the league with Justin Herbert, Keenan Allen and Joey Bosa just some of the names playing hurt or sidelined for Sunday. Which NFL odds should you target this week? There are four underdogs of at least four points in the Week 4 NFL schedule, including the Texans against the Chargers (-5) and the Patriots against the Packers (-9.5). Underdogs of four-plus points are 17-8 ATS (68%), which is the best record after three weeks since 2000. Bettors should take note of the successful start for NFL underdogs against the spread this season before making any Week 4 NFL picks.